🧬 How chemotherapy reshapes tumors—one clone at a time
Using single‑cell barcoding and scRNA‑seq across breast cancer xenografts, we show that chemotherapy rapidly rewires the tumor cellular clonal landscape. Treatment selects for previously rare, resistant cell clones, with distinct responses across cell states and subtypes. Stress‑adaptive, slow‑cycling “persister” programs—marked by DUSP1 and KLF4—emerge in ER+/HER2− models, revealing new insights into chemotherapy tolerance.
🔬 Tracking resistance at single‑clone resolution changes how we think about treatment failure.
🚨 Check out our pre-print Kronheim S et al. bioRxiv 2026: https://doi.org/10.64898/2026.04.02.716097
#CancerResearch #SingleCell #Chemotherapy #TumorEvolution