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Pre-print alert! Chemotherapy reshapes cellular clonal landscape via persister programs in breast cancer xenografts
𧏠How chemotherapy reshapes tumorsâone clone at a timeUsing singleâcell barcoding and scRNAâseq across breast cancer xenografts, we show that chemotherapy rapidly rewires the tumor cellular clonal landscape. Treatment selects for previously rare, resistant cell clones, with distinct responses across cell states and subtypes. Stressâadaptive, slowâcycling âpersisterâ programsâmarked by DUSP1 and KLF4âemerge in ER+/HER2â models,…
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Welcome Dr. Jiahui (Jacob) Wang to the Nguyen lab!
Weâre thrilled to welcome Dr. Jiahui (Jacob) Wang as the newest member of our lab! Jacob joins us with a PhD in Physiology, Cell and Developmental Biology from the University of Alberta and brings valuable industry experience from his previous role as a Scientist. Jacobâs position is supported by the Canada Leads 100 Challenge through…
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New publication alert!
The latest publication from the Nguyen, Caldas and Rueda labs. This was a massive effort from a fantastic team and we’re grateful to everyone on the paper for their work on this project! https://doi.org/10.1016/j.celrep.2025.115699 In this paper we used expressed lentiviral barcoding to track the clonal growth of over 20,000 single-cell-derived clones in 110 xenografts…
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Dr. Sarah Kronheim receives the Research Training Award from the Canadian Cancer Society!
Congratulations to Sarah on this award for her project “Identifying cells inside breast tumours which drive chemotherapy resistance”. With funding from the Canadian Cancer Society, Sarah is researching why some cells within breast tumours respond differently to chemotherapies. If successful, this project could lead to new ways of targeting breast cancer cells that are resistant…
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Congratulations Hayley!
Heejin Hayley Shin is a PhD student in the Nguyen lab who was awarded the MBP Excellence UTF scholarship. This is funded by an endowment created by Ontario Cancer Institute/Princess Margaret Cancer Centre, the Province of Ontario and the University of Toronto. Congratulations Hayley, way to go!
Nguyen Lab
